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The basis for specific changes in differentiation that accompany ras-oncogene-mediated transformation are not understood. When short-term cultures of fibroblast-like cells from adult rat adrenal glands were transformed with Kirsten murine sarcoma virus Ki-MSVthe original stromal characteristics of the target cells metachromatic extracellular matrix, high collagen production, collagen incorporation into pericellular matrix and a fibroblastic morphology and growth pattern diminished.

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Background: Tuberculous meningitis remains a frequently diagnosed entity in urban US hospitals, with the incidence increasing as a consequence of infection with the human immunodeficiency virus HIV. Objective: To describe the adult vk, characteristics, and therapeutic responses of tuberculous meningitis among adult patients of an urban public hospital, with special attention to the effects of HIV infection. De: Retrospective clinical review of all cases identified among adults over a year interval, collecting demographic and clinical variables. Setting: A bed urban teaching hospital. Main outcome measure: Nine-month outcome stratified by survival.

Cumulative rates of occurrence per persons over the 12 years of the study were estimated at 1. HIV infection had no discernible effect on findings. Conclusions: Tuberculous meningitis remains relatively common among indigent urban nonwhite populations.

While HIV infection has contributed to the increased incidence of tuberculous meningitis, it has not ificantly altered the presenting clinical, laboratory, or radiographic findings or the response to therapy of adult vk disease. Parameters associated in a multivariate regression analysis with mortality at 9 months were black race and the absence of corticosteroid use. Please enable it to take advantage of the complete set of features!

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Tuberculous meningitis among adults with and without hiv infection. experience in an urban public hospital

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Similar articles The influence of HIV infection on clinical presentation, response to treatment, and outcome in adults adult vk Tuberculous meningitis.

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Thwaites GE, et al. J Infect Dis. Epub Nov PMID: Isoniazid resistance, mycobacterial genotype and outcome in Vietnamese adults with tuberculous meningitis. Int J Tuberc Lung Dis. Tuberculous meningitis in HIV-infected patients in Brazil: clinical and laboratory characteristics and factors associated with mortality. Croda MG, et al.

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Int J Infect Dis. Epub Dec Presentation of 21 cases]. Arzuaga JA, et al. Enferm Infecc Microbiol Clin. PMID: Review. Tuberculous meningitis in adults: review of 61 cases. See all similar articles.

Cook AM, et al. Neurocrit Care. Treatment outcomes and risk factors of extra-pulmonary tuberculosis in patients with co-morbidities. Khan AH, et al. BMC Infect Dis. Abulfathi AA, et al. Clin Pharmacokinet. Mortality in hospitalized patients with tuberculous meningitis.

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Soria J, et al. Mezochow A, et al. Curr Neurol Neurosci Rep. See all "Cited by" articles. MeSH terms Adult Actions.

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